Hesperidin is the signature flavonoid of the orange, a flavanone found chiefly in the white pith and segment walls of citrus fruit. It is the compound that gives oranges and tangerines much of their reputation for supporting the circulation. Sweet oranges are by far the richest everyday source; grapefruit contains only a little, its flavanone profile dominated instead by naringin. Enjoyed as part of the whole fruit, hesperidin is one of the gentle reasons citrus has long been linked with a healthy heart.
What is Hesperidin?
Hesperidin is a flavonoid that plays a critical role in supporting the health of the blood vessels and circulation, helping to improve the function of the endothelium, the delicate inner lining of the arteries that governs how readily they relax and widen. While many general diets overlook it, maintaining optimal levels of Hesperidin is frequently tracked by people working to optimize their Blood Pressure.
Top Foods High in Hesperidin
A data-driven breakdown of the foods with the highest concentration of Hesperidin per 100 g.
| Food | Hesperidin |
|---|---|
| Orange | 15 mg |
| Grapefruit | 2.8 mg |
How Hesperidin Impacts Blood Pressure
Research links diets rich in Hesperidin to changes in Blood Pressure. Diets naturally abundant in this compound often support lower Blood Pressure markers by improving the function of the endothelium that lines the arteries and easing inflammation within the vessel wall, which together help the blood vessels relax and support healthier blood pressure.
Scientific references & clinical evidence
This guide is built on peer-reviewed research — verify the primary sources below.
Written by the Nutrition Encyclopedia team · medically reviewed by Dr. Sunaina Tariq, MBBS
Last updated 22 June 2026
How we source & verify data · Medical disclaimer
Nutrition values are approximations compiled from public food-composition databases (USDA FoodData Central) and are provided for educational purposes only — not medical advice.
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